Interfacial nano-biosensing in microfluidic droplets for high-sensitivity detection of low-solubility molecules

Microfluidic generation of monodisperse ultra-low interfacial tension oil droplets in water

Microfluidic Systems for Biosensing

In the past two decades, Micro Fluidic Systems (MFS) have emerged as a powerful tool for biosensing, particularly in enriching and purifying molecules and cells in biological samples. Compared with conventional sensing techniques, distinctive advantages of using MFS for biomedicine include ultra-high sensitivity, higher throughput, in-situ monitoring and lower cost. This review aims to summariz...

A Microfluidic Platform for the Production of Monodisperse Ultralow Interfacial Tension Oil Droplets in Water

We present a novel microfluidic approach for the generation of monodisperse oil droplets in water with ultra-low interfacial tensions. Using an oil-water-surfactant formulation under conditions close to the microemulsion phase transition, we actively controlled the surface tension at the liquid-liquid interface within the microfluidic device in order to produce monodisperse droplets. These drop...

Label-free high-throughput detection and content sensing of individual droplets in microfluidic systems.

This study reports a microwave-microfluidics integrated approach capable of performing droplet detection at high-throughput as well as content sensing of individual droplets without chemical or physical intrusion. The sensing system consists of a custom microwave circuitry and a spiral-shaped microwave resonator that is integrated with microfluidic chips where droplets are generated. The microw...

High-temperature microfluidic synthesis of CdSe nanocrystals in nanoliter droplets.

The high-temperature synthesis of CdSe nanocrystals in nanoliter-volume droplets flowing in a perfluorinated carrier fluid through a microfabricated reactor is presented. A flow-focusing nanojet structure with a step increase in channel height reproducibly generated octadecene droplets in Fomblin Y 06/6 perfluorinated polyether at capillary numbers up to 0.81 and with a droplet:carrier fluid vi...